RT Journal Article
SR Electronic
T1 Single-neuron spiking variability in hippocampus dynamically tracks sensory content during memory formation in humans
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2023.02.23.529684
DO 10.1101/2023.02.23.529684
A1 Leonhard Waschke
A1 Fabian Kamp
A1 Evi van den Elzen
A1 Suresh Krishna
A1 Ulman Lindenberger
A1 Ueli Rutishauser
A1 Douglas D. Garrett
YR 2023
UL http://biorxiv.org/content/early/2023/02/23/2023.02.23.529684.abstract
AB During memory formation, the hippocampus is presumed to represent the “content” of stimuli, but how it does so is unknown. Using computational modelling and human single-neuron recordings, we show that the more precisely hippocampal spiking variability tracks the composite features that comprise each individual stimulus, the better those stimuli are later remembered. We propose that moment-to-moment spiking variability may provide a new window into how the hippocampus constructs memories from the building blocks of our sensory world.Competing Interest StatementThe authors have declared no competing interest.