RT Journal Article
SR Electronic
T1 In vivo ephaptic coupling allows memory network formation
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2023.02.28.530474
DO 10.1101/2023.02.28.530474
A1 Dimitris A. Pinotsis
A1 Earl K. Miller
YR 2023
UL http://biorxiv.org/content/early/2023/03/01/2023.02.28.530474.abstract
AB It is increasingly clear that memories are distributed across multiple brain areas. Such “engram complexes” are important features of memory formation and consolidation. Here, we test the hypothesis that engram complexes are formed in part by bioelectric fields that sculpt and guide the neural activity and tie together the areas that participate in engram complexes. Like the conductor of an orchestra, the fields influence each musician or neuron and orchestrate the output, the symphony. Our results use the theory of synergetics, machine learning and data from a spatial delayed saccade task and provide evidence for in vivo ephaptic coupling in memory representations.Competing Interest StatementThe authors have declared no competing interest.