RT Journal Article SR Electronic T1 WheatNet: A genome-scale functional network for hexaploid bread wheat, Triticum aestivum JF bioRxiv FD Cold Spring Harbor Laboratory SP 105098 DO 10.1101/105098 A1 Tak Lee A1 Sohyun Hwang A1 Chan Yeong Kim A1 Hongseok Shim A1 Hyojin Kim A1 Pamela C. Ronald A1 Edward M. Marcotte A1 Insuk Lee YR 2017 UL http://biorxiv.org/content/early/2017/02/06/105098.abstract AB Gene networks provide a system-level overview of genetic organizations and enable the dissection of functional modules underlying complex traits. Here we report the generation of WheatNet, the first genome-scale functional network for T. aestivum and a companion web server (www.inetbio.org/wheatnet). WheatNet was constructed by integrating 20 distinct genomics datasets, including 156,000 wheat-specific co-expression links mined from 1,929 microarray data. A unique feature of WheatNet is that each network node represents either a single gene or a group of genes. We computationally partitioned gene groups mimicking homeologous genes by clustering 99,386 wheat genes, resulting in 20,248 gene groups comprising 63,401 genes and 35,985 individual genes. Thus, WheatNet was constructed using 56,233 nodes, and the final integrated network has 20,230 nodes and 567,000 edges. The edge information of the integrated WheatNet and all 20 component networks are available for download.