RT Journal Article
SR Electronic
T1 Running modulates primate and rodent visual cortex differently
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2022.06.13.495712
DO 10.1101/2022.06.13.495712
A1 Liska, John P.
A1 Rowley, Declan P.
A1 Nguyen, Trevor T. K.
A1 Muthmann, Jens-Oliver
A1 Butts, Daniel A.
A1 Yates, Jacob L.
A1 Huk, Alexander C.
YR 2023
UL http://biorxiv.org/content/early/2023/03/14/2022.06.13.495712.abstract
AB When mice run, activity in their primary visual cortex (V1) is strongly modulated. This observation has altered conception of a brain region assumed to be a passive image processor. Extensive work has followed to dissect the circuits and functions of running-correlated modulation. However, it remains unclear whether visual processing in primates might similarly change during locomotion. We measured V1 activity in marmosets while they viewed stimuli on a treadmill. In contrast to mouse V1, marmoset V1 was slightly but reliably suppressed during running. Population-level analyses revealed trial-to-trial fluctuations of shared gain across V1 in both species, but these gain modulations were smaller and more often negatively correlated with running in marmosets. Thus, population-scale gain fluctuations of V1 reflect a common feature of mammalian visual cortical function, but important quantitative differences yield distinct consequences for the relation between vision and action in primates versus rodents.Competing Interest StatementThe authors have declared no competing interest.