RT Journal Article
SR Electronic
T1 Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2023.03.16.532850
DO 10.1101/2023.03.16.532850
A1 Jerika J. Barron
A1 Nicholas M. Mroz
A1 Sunrae E. Taloma
A1 Madelene W. Dahlgren
A1 Jorge Ortiz-Carpena
A1 Leah C. Dorman
A1 Ilia D. Vainchtein
A1 Caroline C. Escoubas
A1 Ari B. Molofsky
A1 Anna V. Molofsky
YR 2023
UL http://biorxiv.org/content/early/2023/03/17/2023.03.16.532850.abstract
AB The innate immune system plays essential roles in brain synaptic development, and immune dysregulation is implicated in neurodevelopmental diseases. Here we show that a subset of innate lymphocytes (group 2 innate lymphoid cells, ILC2s) is required for cortical inhibitory synapse maturation and adult social behavior. ILC2s expanded in the developing meninges and produced a surge of their canonical cytokine Interleukin-13 (IL-13) between postnatal days 5-15. Loss of ILC2s decreased cortical inhibitory synapse numbers in the postnatal period where as ILC2 transplant was sufficient to increase inhibitory synapse numbers. Deletion of the IL-4/IL-13 receptor (Il4ra) from inhibitory neurons phenocopied the reduction inhibitory synapses. Both ILC2 deficient and neuronal Il4ra deficient animals had similar and selective impairments in adult social behavior. These data define a type 2 immune circuit in early life that shapes adult brain function.One sentence summary Type 2 innate lymphoid cells and Interleukin-13 promote inhibitory synapse development.Competing Interest StatementThe authors have declared no competing interest.