RT Journal Article
SR Electronic
T1 The house spider genome reveals an ancient whole-genome duplication during arachnid evolution
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 106385
DO 10.1101/106385
A1 Evelyn E. Schwager
A1 Prashant P. Sharma
A1 Thomas Clarke
A1 Daniel J. Leite
A1 Torsten Wierschin
A1 Matthias Pechmann
A1 Yasuko Akiyama-Oda
A1 Lauren Esposito
A1 Jesper Bechsgaard
A1 Trine Bilde
A1 Alexandra D. Buffry
A1 Hsu Chao
A1 Huyen Dinh
A1 Harsha Vardhan Doddapaneni
A1 Shannon Dugan
A1 Cornelius Eibner
A1 Cassandra G. Extavour
A1 Peter Funch
A1 Jessica Garb
A1 Vanessa L. Gonzalez
A1 Sam Griffiths-Jones
A1 Yi Han
A1 Cheryl Hayashi
A1 Maarten Hilbrant
A1 Daniel S.T. Hughes
A1 Ralf Janssen
A1 Sandra L. Lee
A1 Ignacio Maeso
A1 Shwetha C. Murali
A1 Donna M. Muzny
A1 Rodrigo Nunes da Fonseca
A1 Jiaxin Qu
A1 Matthew Ronshaugen
A1 Christoph Schomburg
A1 Anna Schönauer
A1 Angelika Stollewerk
A1 Montserrat Torres-Oliva
A1 Natascha Turetzek
A1 Bram Vanthournout
A1 Jack Werren
A1 Carsten Wolff
A1 Kim C. Worley
A1 Gregor Bucher
A1 Richard A. Gibbs
A1 Jonathan Coddington
A1 Hiroki Oda
A1 Mario Stanke
A1 Nadia A. Ayoub
A1 Nikola-Michael Prpic
A1 Jean-François Flot
A1 Nico Posnien
A1 Stephen Richards
A1 Alistair P. McGregor
YR 2017
UL http://biorxiv.org/content/early/2017/02/08/106385.abstract
AB The duplication of genes can occur through various mechanisms and is thought to make a major contribution to the evolutionary diversification of organisms. There is increasing evidence for a large-scale duplication of genes in some chelicerate lineages including two rounds of whole genome duplication (WGD) in horseshoe crabs. To investigate this further we sequenced and analyzed the genome of the common house spider Parasteatoda tepidariorum. We found pervasive duplication of both coding and non-coding genes in this spider, including two clusters of Hox genes. Analysis of synteny conservation across the P. tepidariorum genome suggests that there has been an ancient WGD in spiders. Comparison with the genomes of other chelicerates, including that of the newly sequenced bark scorpion Centruroides sculpturatus, suggests that this event occurred in the common ancestor of spiders and scorpions and is probably independent of the WGDs in horseshoe crabs. Furthermore, characterization of the sequence and expression of the Hox paralogs in P. tepidariorum suggests that many have been subject to neofunctionalization and subfunctionalization since their duplication, and therefore may have contributed to the diversification of spiders and other pulmonate arachnids.