RT Journal Article SR Electronic T1 Changes in large-scale neural networks under stress are linked to affective reactivity to stress in real life JF bioRxiv FD Cold Spring Harbor Laboratory SP 2023.03.28.534537 DO 10.1101/2023.03.28.534537 A1 Tutunji, Rayyan A1 Krentz, Martin A1 Kogias, Nikos A1 de Voogd, Lycia A1 Krause, Florian A1 Vassena, Eliana A1 Hermans, Erno J. YR 2023 UL http://biorxiv.org/content/early/2023/03/28/2023.03.28.534537.abstract AB Controlled laboratory stress induction procedures are very effective in inducing physiological and subjective stress. However, whether such stress responses are representative for stress reactivity in real life is not clear. Using a combined within-subject functional MRI laboratory stress and ecological momentary assessment stress paradigm, we investigated dynamic shifts in large-scale neural network configurations under stress and how these relate to affective reactivity to stress in real life. Laboratory stress induction resulted in significantly increased cortisol levels, and shifts in task-driven neural activity. Namely, increased salience network (SN) activation in an oddball task and decreased default mode network activity in a memory retrieval task. Crucially, individuals showing increased SN reactivity specifically in the early phase of the acute stress response also expressed increased affective reactivity in real life. Our findings provide (correlational) evidence that real-life affective stress reactivity is driven primarily by vigilant attentional reorientation mechanisms associated with SN.Competing Interest StatementThe authors have declared no competing interest.