RT Journal Article
SR Electronic
T1 The emergence of new lineages of the Mpox virus could affect the 2022 outbreak
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2022.07.07.498743
DO 10.1101/2022.07.07.498743
A1 Mayla Abrahim
A1 Alexandro Guterres
A1 Patrícia Cristina da Costa Neves
A1 Ana Paula Dinis Ano Bom
YR 2023
UL http://biorxiv.org/content/early/2023/03/31/2022.07.07.498743.abstract
AB Human Mpox is a highly contagious viral disease caused by Mpox virus, currently causing outbreaks in various regions of the world and considered a global public health problem. Understanding how the virus adapts or transfers to a new host species is crucial for effective prevention and treatment of viral infections. A comprehensive analysis of 1,318 accessible Mpox genomes was conducted to assess potential phenotypic effects, incorporating the examination of pseudogenes, gene duplication and deletion, as well as sequences obtained from the 2022 outbreak. This study we analyzed the genomic sequences of Mpox viruses from different clades and found that only a small percentage of proteins were conserved across the analyzed clades, with many proteins exhibiting various mutations, indicating the potential correlation between lineage or clade and variations in the pathology of human Mpox disease. The study highlights the importance of analyzing aligned regions in viral genomes to understand the evolution of the virus and the impact of structural changes on protein functions. In brief, further investigations are required to establish a correlation between the effects of these genetic modifications and the novel transmission pathways, average age, clinical manifestations, and symptoms observed in the ongoing outbreak.Competing Interest StatementThe authors have declared no competing interest.