RT Journal Article
SR Electronic
T1 Diverging maternal and infant cord antibody functions from SARS-CoV-2 infection and vaccination in pregnancy
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2023.05.01.538955
DO 10.1101/2023.05.01.538955
A1 Emily H. Adhikari
A1 Pei Lu
A1 Ye jin Kang
A1 Ann R. McDonald
A1 Jessica E. Pruszynski
A1 Timothy A. Bates
A1 Savannah K. McBride
A1 Mila Trank-Greene
A1 Fikadu G. Tafesse
A1 Lenette L. Lu
YR 2023
UL http://biorxiv.org/content/early/2023/05/02/2023.05.01.538955.abstract
AB Immunization in pregnancy is a critical tool that can be leveraged to protect the infant with an immature immune system but how vaccine-induced antibodies transfer to the placenta and protect the maternal-fetal dyad remains unclear. Here, we compare matched maternal-infant cord blood from individuals who in pregnancy received mRNA COVID-19 vaccine, were infected by SARS-CoV-2, or had the combination of these two immune exposures. We find that some but not all antibody neutralizing activities and Fc effector functions are enriched with vaccination compared to infection. Preferential transport to the fetus of Fc functions and not neutralization is observed. Immunization compared to infection enriches IgG1-mediated antibody functions with changes in antibody post-translational sialylation and fucosylation that impact fetal more than maternal antibody functional potency. Thus, vaccine enhanced antibody functional magnitude, potency and breadth in the fetus are driven more by antibody glycosylation and Fc effector functions compared to maternal responses, highlighting prenatal opportunities to safeguard newborns as SARS-CoV-2 becomes endemic.One Sentence Summary SARS-CoV-2 vaccination in pregnancy induces diverging maternal and infant cord antibody functionsCompeting Interest StatementThe authors have declared no competing interest.