TY - JOUR T1 - Quantifying GC-biased gene conversion in great ape genomes using polymorphism-aware models JF - bioRxiv DO - 10.1101/380246 SP - 380246 AU - Rui Borges AU - Gergely Szöllősi AU - Carolin Kosiol Y1 - 2019/01/01 UR - http://biorxiv.org/content/early/2019/03/20/380246.abstract N2 - As multi-individual population-scale data is becoming available, more-complex modeling strategies are needed to quantify the genome-wide patterns of nucleotide usage and associated mechanisms of evolution. Recently, the multivariate neutral Moran model was proposed. However, it was shown insufficient to explain the distribution of alleles in great apes. Here, we propose a new model that includes allelic selection. Our theoretical results constitute the basis of a new Bayesian framework to estimate mutation rates and selection coefficients from population data. We employ the new framework to a great ape dataset at we found patterns of allelic selection that match those of genome-wide GC-biased gene conversion (gBCG). In particular, we show that great apes have patterns of allelic selection that vary in intensity, a feature that we correlated with the great apes’ distinct demographies. We also demonstrate that the AT/GC toggling effect decreases the probability of a substitution, promoting more polymorphisms in the base composition of great ape genomes. We further assess the impact of CG-bias in molecular analysis and we find that mutation rates and genetic distances are estimated under bias when gBGC is not properly accounted. Our results contribute to the discussion on the tempo and mode of gBGC evolution, while stressing the need for gBGC-aware models in population genetics and phylogenetics. ER -