PT  - JOURNAL ARTICLE
AU  - Zhi, Da
AU  - Shahshahani, Ladan
AU  - Nettekoven, Caroline
AU  - Pinho, Ana Lúısa
AU  - Bzdok, Danilo
AU  - Diedrichsen, Jörn
TI  - A hierarchical Bayesian brain parcellation framework for fusion of functional imaging datasets
AID  - 10.1101/2023.05.24.542121
DP  - 2023 Jan 01
TA  - bioRxiv
PG  - 2023.05.24.542121
4099  - http://biorxiv.org/content/early/2023/05/24/2023.05.24.542121.short
4100  - http://biorxiv.org/content/early/2023/05/24/2023.05.24.542121.full
AB  - One important barrier in the development of complex models of human brain organization is the lack of a large and comprehensive task-based neuro-imaging dataset. Therefore, current atlases of functional brain organization are mainly based on single and homogeneous resting-state datasets. Here, we propose a hierarchical Bayesian framework that can learn a probabilistically defined brain parcellation across numerous task-based and resting-state datasets, exploiting their combined strengths. The framework is partitioned into a spatial arrangement model that defines the probability of a specific individual brain parcellation, and a set of dataset-specific emission models that defines the probability of the observed data given the individual brain organization. We show that the framework optimally combines information from different datasets to achieve a new population-based atlas of the human cerebellum. Furthermore, we demonstrate that, using only 10 min of individual data, the framework is able to generate individual brain parcellations that outperform group atlases.Competing Interest StatementThe authors have declared no competing interest.