RT Journal Article
SR Electronic
T1 Enhanced late blight resistance by engineering an EpiC2B-insensitive immune protease
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2023.05.29.541874
DO 10.1101/2023.05.29.541874
A1 Schuster, Mariana
A1 Eisele, Sophie
A1 Armas-Egas, Liz
A1 Kessenbrock, Till
A1 Kourelis, Jiorgos
A1 Kaiser, Markus
A1 van der Hoorn, Renier A. L.
YR 2023
UL http://biorxiv.org/content/early/2023/05/29/2023.05.29.541874.abstract
AB Crop protection strategies relying on the improvement of the natural plant immune system via genetic engineering are sustainable solutions against the pathogen thread on food security. Here we describe a novel way to improve the plant immune system by immune protease engineering. As proof of concept, we increased resistance against the late blight pathogen Phytopththora infestans by rendering the tomato secreted immune protease Pip1 insensitive to the P. infestans-secreted inhibitor Epic2B. This concept can be applied to secreted immune proteases in crops by precision breeding.Competing Interest StatementThe authors have declared no competing interest.