RT Journal Article
SR Electronic
T1 Replication and characterization of <em>CADM2</em> and <em>MSRA</em> genes on human behavior
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 110395
DO 10.1101/110395
A1 Brian Boutwell
A1 David Hinds
A1 the 23andMe Research Team
A1 Jorim Tielbeek
A1 Ken K. Ong
A1 Felix R. Day
A1 John R.B. Perry
YR 2017
UL http://biorxiv.org/content/early/2017/02/21/110395.abstract
AB Progress identifying the genetic determinants of personality has historically been slow, with candidate gene studies and small-scale genome-wide association studies yielding few reproducible results. In the UK Biobank study, genetic variants in CADM2 and MSRA were recently shown to influence risk taking behavior and irritability respectively, representing some of the first genomic loci to be associated with aspects of personality. We extend this observation by performing a personality “phenome-scan” across 16 traits in up to 140,487 participants from 23andMe for these two genes. Heritability estimates for these traits ranged from 5-19%, with both CADM2 and MSRA demonstrating significant effects on multiple personality types. These associations covered all aspects of the big five personality domains, including specific facet traits such as compliance, altruism, anxiety and activity / energy. This study both confirms and extends the original observations, highlighting the role of genetics in aspects of mental health and behavior.