RT Journal Article
SR Electronic
T1 Self-reported sleep duration and daytime napping are associated with renal hyperfiltration and microalbuminuria in apparently healthy Chinese population
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 585190
DO 10.1101/585190
A1 Yingnan Ye
A1 Linxi Zhang
A1 Wenhua Yan
A1 Anping Wang
A1 Weiqing Wang
A1 Zhengnan Gao
A1 Xulei Tang
A1 Li Yan
A1 Qin Wan
A1 Zuojie Luo
A1 Guijun Qin
A1 Lulu Chen
A1 Shiqing Wang
A1 Yuxia Wang
A1 Yiming Mu
YR 2019
UL http://biorxiv.org/content/early/2019/03/21/585190.abstract
AB Background Sleep duration affects health in various way. The objective of this study was to investigate the relationship between sleep duration, daytime napping and kidney function in a middle-aged apparently healthy Chinese population.Methods According to self-reported total sleep and daytime napping duration, 33,850 participants aged 38 to 90 years old from 8 regional centers were divided into subgroups. Height, weight, waistline, hipline, blood pressure, biochemical index, FBG, PBG, HbA1c, creatinine and urinary albumin-creatinine ratio (UACR) were measured and recorded in each subject. Microalbuminuria was defined as UACR>=30 mg/g, CKD was defined as eGFR<60 ml/min and hyperfiltration was defined as eGFR>=135 ml/min. Multiple logistic regressions were applied to investigate associations between sleep and kidney function.Results Compared to participants with [7-8]h/day sleep, ORs of >9 h/day, (8, 9]h/day and <6h/day sleep for microalbuminuria were 1.317 (1.200-1.446, p<0.001), 1.215 (1.123-1.315, p<0.001) and 1.218 (0.967-1.534, p=0.094). eGFR levels were U-shaped associated with sleep duration among subjects with >=90ml/min eGFR, and N-shaped associated with sleep duration among subjects with <90ml/min eGFR. OR of >9h/day sleep for hyperfiltration was 1.400 (1.123-1.745, p=0.003) among eGFR>=90 ml/min participants. Daytime napping had a negative effect on renal health. Compared to participants did not have napping habit, the ORs of (0, 1]h/day, (1, 1.5]h/day and >1.5h/day daytime napping for microalbuminuria were 1.477 (1.370-1.591, p<0.001), 1.217 (1.056, 1.403, p=0.007) and 1.447 (1.242, 1.687, p<0.001).Conclusions Total sleep duration are U-shaped associated with renal health outcomes. Daytime napping had a negative effect on renal health.