RT Journal Article
SR Electronic
T1 mRNA vaccine induces protective immunity against the type III secretory virulence of <em>Pseudomonas aeruginosa</em>
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2023.06.09.544431
DO 10.1101/2023.06.09.544431
A1 Kawaguchi, Ken
A1 Kinoshita, Mao
A1 Sudo, Kazuki
A1 Inoue, Keita
A1 Naito, Yoshifumi
A1 Oba, Makoto
A1 Uchida, Satoshi
A1 Sawa, Teiji
YR 2023
UL http://biorxiv.org/content/early/2023/06/10/2023.06.09.544431.abstract
AB Few studies have addressed mRNA vaccination against bacteria despite the desperate need to control antimicrobial resistance. Herein, we developed mRNA vaccines targeting the type III secretion system of Pseudomonas aeruginosa, which plays a critical role in the pathogenesis. Vaccination with a nucleoside-modified mRNA encapsulated in lipid nanoparticles improved mouse survival, reduced the bacterial load in the lung, and alleviated pathological changes in the lungs after bacterial challenge.Competing Interest StatementS.U is a founder of Crafton Biotechnology.