RT Journal Article
SR Electronic
T1 Stimulus-specific enhancement of responses in mouse primary visual cortex mediated by GABA release from VIP cells
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2023.06.19.545641
DO 10.1101/2023.06.19.545641
A1 Kaneko, Megumi
A1 Hoseini, Mahmood S.
A1 Waschek, James A.
A1 Stryker, Michael P.
YR 2023
UL http://biorxiv.org/content/early/2023/06/20/2023.06.19.545641.abstract
AB When adult mice are repeatedly exposed to a particular visual stimulus for as little as one hour per day for several days while their visual cortex (V1) is in the high-gain state produced by locomotion, that specific stimulus elicits much stronger responses in V1 neurons for the following several weeks, even when measured in anesthetized animals. Such stimulus-selective enhancement (SSE) is not seen if locomotion is prevented. The effect of locomotion on cortical responses is mediated by vasoactive intestinal peptide (VIP) positive interneurons, which can release both the peptide and the inhibitory neurotransmitter GABA. Here we used genetic ablation to determine which of those molecules secreted by VIP-ergic neurons is responsible for SSE. SSE was not impaired by VIP deletion but was prevented by compromising release of GABA from VIP cells. This finding suggests that SSE may result from Hebbian mechanisms that remain present in adult V1.Competing Interest StatementThe authors have declared no competing interest.