RT Journal Article
SR Electronic
T1 Thermal transients excite neurons through universal intramembrane mechano-electrical effects
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 111724
DO 10.1101/111724
A1 Michael Plaksin
A1 Eitan Kimmel
A1 Shy Shoham
YR 2017
UL http://biorxiv.org/content/early/2017/02/25/111724.abstract
AB Modern advances in neurotechnology rely on effectively harnessing physical tools and insights towards remote neural control, thereby creating major new scientific and therapeutic opportunities. Specifically, rapid temperature pulses were shown to increase membrane capacitance, causing capacitive currents that explain neural excitation, but the underlying biophysics is not well understood. Here, we show that an intramembrane thermal-mechanical effect wherein the phospholipid bilayer undergoes axial narrowing and lateral expansion accurately predicts a potentially universal thermal capacitance increase rate of ~0.3%/°C. This capacitance increase and concurrent changes in the surface charge related fields lead to predictable exciting ionic displacement currents. The new theory’s predictions provide an excellent agreement with multiple experimental results and indirect estimates of latent biophysical quantities. Our results further highlight the role of electro-mechanics in neural excitation; they may also help illuminate sub-threshold and novel physical cellular effects, and could potentially lead to advanced new methods for neural control.