RT Journal Article SR Electronic T1 Making Biomedical Research Software FAIR: Actionable Step-by-step Guidelines with a User-support Tool JF bioRxiv FD Cold Spring Harbor Laboratory SP 2022.04.18.488694 DO 10.1101/2022.04.18.488694 A1 Patel, Bhavesh A1 Soundarajan, Sanjay A1 Ménager, Hervé A1 Hu, Zicheng YR 2023 UL http://biorxiv.org/content/early/2023/07/06/2022.04.18.488694.abstract AB Findable, Accessible, Interoperable, and Reusable (FAIR) guiding principles tailored for research software have been proposed by the FAIR for Research Software (FAIR4RS) Working Group. They provide a foundation for optimizing the reuse of research software. The FAIR4RS principles are, however, aspirational and do not provide practical instructions to the researchers. To fill this gap, we propose in this work the first actionable step-by-step guidelines for biomedical researchers to make their research software compliant with the FAIR4RS principles. We designate them as the FAIR Biomedical Research Software (FAIR-BioRS) guidelines. Our process for developing these guidelines, presented here, is based on an in-depth study of the FAIR4RS principles and a thorough review of current practices in the field. To support researchers, we have also developed a workflow that streamlines the process of implementing these guidelines. This workflow is incorporated in FAIRshare, a free and open-source software application aimed at simplifying the curation and sharing of FAIR biomedical data and software through user-friendly interfaces and automation. Details about this tool are also presented.Competing Interest StatementThe authors have declared no competing interest.