RT Journal Article
SR Electronic
T1 Chlorpheniramine Maleate Displays Multiple Modes of Antiviral Action Against SARS-CoV-2: A Mechanistic Study
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2023.08.28.554806
DO 10.1101/2023.08.28.554806
A1 Elshaier, Yaseen A. M. M.
A1 Mostafa, Ahmed
A1 Valerio-Pascua, Fernando
A1 Tesch, Mari L.
A1 Costin, Joshua M.
A1 Rahaghi, Franck F.
YR 2023
UL http://biorxiv.org/content/early/2023/08/29/2023.08.28.554806.abstract
AB Chlorpheniramine Maleate (CPM) has been identified as a potential antiviral compound against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). In this study, we investigated the in vitro effects of CPM on key stages of the SARS-CoV-2 replication cycle, including viral adsorption, replication inhibition, and virucidal activity. Our findings demonstrate that CPM exhibits antiviral properties by interfering with viral adsorption, replication, and directly inactivating the virus. Molecular docking analysis revealed interactions between CPM and essential viral proteins, such as the main protease receptor, spike protein receptor, and RNA polymerase. CPM’s interactions were primarily hydrophobic in nature, with an additional hydrogen bond formation in the RNA polymerase active site. These results suggest that CPM has the potential to serve as a multitarget antiviral agent against SARS-CoV-2 and potentially other respiratory viruses. Further investigations are warranted to explore its clinical implications and assess its efficacy in vivo.Competing Interest StatementThe authors have declared no competing interest.