RT Journal Article
SR Electronic
T1 Functional networks of inhibitory neurons orchestrate synchrony in the hippocampus
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2023.09.18.558335
DO 10.1101/2023.09.18.558335
A1 Marco Bocchio
A1 Artem Vorobyev
A1 Sadra Sadeh
A1 Sophie Brustlein
A1 Robin Dard
A1 Susanne Reichinnek
A1 Valentina Emiliani
A1 Claudia Clopath
A1 Rosa Cossart
YR 2023
UL http://biorxiv.org/content/early/2023/09/18/2023.09.18.558335.abstract
AB Inhibitory interneurons are a critical component of cortical circuits. Beyond providing inhibition, they have been proposed to coordinate the firing of excitatory neurons within cell assemblies. While many studies have dissected the function of specific interneuron subtypes, the relationship between interneurons and pyramidal cell synchrony in vivo remains unclear. We use an all-optical approach to simultaneously record hippocampal interneurons and pyramidal cells, and test the network influence of single interneurons. We show that CA1 interneurons form a functionally interconnected network that promotes synchrony through disinhibition during awake immobility without altering endogenous cell assemblies. A network model indicates that cell assemblies and dense but unspecific connectivity between interneurons are necessary ingredients to explain our experimental results. Thus, interneurons may not only operate via division of labor, but also through concerted activity. Our data challenge the idea of a purely decorrelating or segregating function of inhibition.Competing Interest StatementThe authors have declared no competing interest.