%0 Journal Article %A Romain D. Cazé %A Amanda J. Foust %A Claudia Clopath %A Simon R. Schultz %T On the distribution and function of synaptic clusters in dendrites %D 2017 %R 10.1101/029330 %J bioRxiv %P 029330 %X Local non-linearities in dendrites render neuronal output dependent on the spatial distribution of synapses. A neuron will activate differently depending on whether active synapses are spatially clustered or dispersed. While this sensitivity can in principle expand neuronal computational capacity, it has thus far been employed in very few learning paradigms. To make use of this sensitivity, groups of correlated neurons need to make contact with distinct dendrites, and this requires a mechanism to ensure the correct distribution of synapses contacting from distinct ensembles. To address this problem, we introduce the requirement that on a short time scale, a pre-synaptic neuron makes a constant number of synapses with the same strength on a post-synaptic neuron. We find that this property enables clusters to distribute correctly and guarantees their functionality. Furthermore, we demonstrate that a change in the input statistics can reshape the spatial distribution of synapses. Finally, we show under which conditions clusters do not distribute correctly, e.g. when cross-talk between dendrites is too strong. As well as providing insight into potential biological mechanisms of learning, this work paves the way for new learning algorithms for artificial neural networks that exploit the spatial distribution of synapses. %U https://www.biorxiv.org/content/biorxiv/early/2017/03/14/029330.full.pdf