PT - JOURNAL ARTICLE AU - Mena, Wilson AU - Baker, Keeley AU - Rubin, Alon AU - Kohli, Shaun AU - Yoo, Yun AU - Ziv, Yaniv AU - Razaei-Mazinani, Charles AU - Fleischmann, Alexander TI - Differential encoding of odor and place in mouse piriform and entorhinal cortex AID - 10.1101/2023.10.05.561119 DP - 2023 Jan 01 TA - bioRxiv PG - 2023.10.05.561119 4099 - http://biorxiv.org/content/early/2023/10/08/2023.10.05.561119.short 4100 - http://biorxiv.org/content/early/2023/10/08/2023.10.05.561119.full AB - Associating odor cues with spatial information in the environment is critical for animal behavior. The lateral entorhinal cortex (LEC) is reciprocally interconnected with cortical areas for olfaction and the hippocampus and thus ideally positioned to integrate olfactory and spatial information. Here, we used mini-endoscopes to record neural activity in the mouse piriform cortex (PCx) and LEC. We show that in head-fixed mice, odor identity could be decoded from LEC ensembles, but less accurately than from PCx. In contrast, in mice freely navigating a linear track, LEC ensemble activity at the odor ports was dominated by positional information. Spatial position along the linear track could be decoded from LEC and PCx activity, with similar accuracy. However, PCx but not LEC exhibited strong behavior-driven modulation of positional information. Together, our data reveal that information about odor cues and spatial information is differentially encoded along the PCx-LEC axis.Competing Interest StatementThe authors have declared no competing interest.