PT - JOURNAL ARTICLE AU - Hutchison, Alan L. AU - Dinner, Aaron R. TI - Correcting for Dependent P-values in Rhythm Detection AID - 10.1101/118547 DP - 2017 Jan 01 TA - bioRxiv PG - 118547 4099 - http://biorxiv.org/content/early/2017/03/20/118547.short 4100 - http://biorxiv.org/content/early/2017/03/20/118547.full AB - There is much interest in using genome-wide expression time series to identify circadian genes. Several methods have been developed to test for rhythmicity in sparsely sampled time series typical of such measurements. Because these methods are statistical in nature, they rely on estimating the probabilities that patterns arise by chance (i.e., p-values). Here we show that leading methods implicitly make inappropriate assumptions of independence when estimating p-values. We show how to correct for the dependence to obtain accurate estimates for statistical significance during rhythm detection.