PT - JOURNAL ARTICLE AU - Turley, Patrick AU - Walters, Raymond K. AU - Maghzian, Omeed AU - Okbay, Aysu AU - Lee, James J. AU - Fontana, Mark Alan AU - Nguyen-Viet, Tuan Anh AU - Furlotte, Nicholas A. AU - , AU - , AU - Magnusson, Patrik AU - Oskarsson, Sven AU - Johannesson, Magnus AU - Visscher, Peter M. AU - Laibson, David AU - Cesarini, David AU - Neale, Benjamin AU - Benjamin, Daniel J. TI - MTAG: Multi-Trait Analysis of GWAS AID - 10.1101/118810 DP - 2017 Jan 01 TA - bioRxiv PG - 118810 4099 - http://biorxiv.org/content/early/2017/03/20/118810.short 4100 - http://biorxiv.org/content/early/2017/03/20/118810.full AB - We introduce Multi-Trait Analysis of GWAS (MTAG), a method for the joint analysis of summary statistics from GWASs of different traits, possibly from overlapping samples. We demonstrate MTAG using data on depressive symptoms (Neff = 354,862), neuroticism (N = 168,105), and subjective well-being (N = 388,538). Compared to 32, 9, and 13 genome-wide significant loci in the single-trait GWASs (most of which are novel), MTAG increases the number of loci to 74, 66, and 60, respectively. Moreover, the association statistics from MTAG yield more informative bioinformatics analyses and, consistent with theoretical calculations, improve prediction accuracy by approximately 25%.