PT  - JOURNAL ARTICLE
AU  - Turley, Patrick
AU  - Walters, Raymond K.
AU  - Maghzian, Omeed
AU  - Okbay, Aysu
AU  - Lee, James J.
AU  - Fontana, Mark Alan
AU  - Nguyen-Viet, Tuan Anh
AU  - Furlotte, Nicholas A.
AU  - , 
AU  - , 
AU  - Magnusson, Patrik
AU  - Oskarsson, Sven
AU  - Johannesson, Magnus
AU  - Visscher, Peter M.
AU  - Laibson, David
AU  - Cesarini, David
AU  - Neale, Benjamin
AU  - Benjamin, Daniel J.
TI  - MTAG: Multi-Trait Analysis of GWAS
AID  - 10.1101/118810
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 118810
4099  - http://biorxiv.org/content/early/2017/03/20/118810.short
4100  - http://biorxiv.org/content/early/2017/03/20/118810.full
AB  - We introduce Multi-Trait Analysis of GWAS (MTAG), a method for the joint analysis of summary statistics from GWASs of different traits, possibly from overlapping samples. We demonstrate MTAG using data on depressive symptoms (Neff = 354,862), neuroticism (N = 168,105), and subjective well-being (N = 388,538). Compared to 32, 9, and 13 genome-wide significant loci in the single-trait GWASs (most of which are novel), MTAG increases the number of loci to 74, 66, and 60, respectively. Moreover, the association statistics from MTAG yield more informative bioinformatics analyses and, consistent with theoretical calculations, improve prediction accuracy by approximately 25%.