RT Journal Article
SR Electronic
T1 Deuteration provides a general strategy to enhance azobenzene-based photopharmacology
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2023.11.09.566420
DO 10.1101/2023.11.09.566420
A1 Roßmann, Kilian
A1 Gonzalez-Hernandez, Alberto J.
A1 Bhuyan, Rahul
A1 Börjesson, Karl
A1 Levitz, Joshua
A1 Broichhagen, Johannes
YR 2023
UL http://biorxiv.org/content/early/2023/11/09/2023.11.09.566420.abstract
AB Herein, we present deuterated azobenzene photoswitches as a general means of enhancing photopharmacological molecules. Deuteration can improve azobenzene performance in terms of light sensitivity, photoswitch efficiency, and photoswitch kinetics with minimal alteration to the underlying structure of the photopharmacological ligand. We report synthesized deuterated azobenzene-based ligands for the optimized optical control of ion channel and G protein-coupled receptor function in live cells, setting the stage for the straightforward, widespread adoption of this approach.Competing Interest StatementThe authors have declared no competing interest.