PT  - JOURNAL ARTICLE
AU  - Forsberg, Simon
AU  - Carlborg, Örjan
TI  - On the relationship between epistasis and genetic variance-heterogeneity
AID  - 10.1101/119727
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 119727
4099  - http://biorxiv.org/content/early/2017/03/23/119727.short
4100  - http://biorxiv.org/content/early/2017/03/23/119727.full
AB  - Epistasis and genetic variance heterogeneity are two non-additive genetic inheritance patterns that are often, but not always, related. Here we use theoretical examples and empirical results from analyses of experimental data to illustrate the connection between the two. This includes an introduction to the relationship between epistatic gene-action, statistical epistasis and genetic variance heterogeneity and a brief discussion about how other genetic processes than epistasis can also give rise to genetic variance heterogeneity.Highlight Genetic effects on the trait variance, rather than the mean, have been found in several studies. Here we discuss how this sometimes, but not always, can be caused by epistasis.GP-spaceGenotype to Phenotype spaceQTLQuantitative Trait LocusGWAGenome Wide AssociationH2Broad sense heritabilityh2Narrow sense heritabilityLDLinkage Disequilibrium