RT Journal Article SR Electronic T1 Ethoscopes: an open platform for high-throughput ethomics JF bioRxiv FD Cold Spring Harbor Laboratory SP 113647 DO 10.1101/113647 A1 Quentin Geissmann A1 Luis Garcia Rodriguez A1 Esteban J Beckwith A1 Alice S French A1 Arian R Jamasb A1 Giorgio F Gilestro YR 2017 UL http://biorxiv.org/content/early/2017/03/24/113647.abstract AB We present ethoscopes, machines for high-throughput ethomics in Drosophila and other small animals. Ethoscopes provide four unique features: they provide a software and hardware solution that is reproducible, scalable and open-source; they perform not just real-time tracking, but faithful real-time profiling of behaviour using a supervised machine learning algorithm; they can stimulate flies in a feedback-loop mode; they are highly customisable and open source.Authors’ contributions QG, LGR and GFG designed the platform; QG and LGR wrote the software; QG and EJB performed the experiments; ARJ contributed the optomotor module; ASF contributed the AGO module; all authors contributed the manuscript.Competing interests The authors declare that no competing interests exist.