RT Journal Article
SR Electronic
T1 A molecular gradient along the longitudinal axis of the human hippocampus informs large-scale behavioral systems
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 587071
DO 10.1101/587071
A1 Jacob W. Vogel
A1 Renaud La Joie
A1 Michel J. Grothe
A1 Alex Diaz-Papkovich
A1 Andrew Doyle
A1 Etienne Vachon-Presseau
A1 Claude Lepage
A1 Reinder Vos de Wael
A1 Yasser Iturria-Medina
A1 Boris Bernhardt
A1 Gil D. Rabinovici
A1 Alan C. Evans
YR 2019
UL http://biorxiv.org/content/early/2019/03/24/587071.abstract
AB The functional organization of the hippocampus is distributed as a gradient along its longitudinal axis that explains its differential interaction with diverse brain systems. We show that the location of human tissue samples extracted along the longitudinal axis of the hippocampus can be predicted within 2mm using the expression pattern of less than 100 genes. When variation in this specific gene expression pattern was observed across the whole brain, a distinct anterioventral-posteriodorsal gradient was observed. Frontal, anterior temporal and brainstem regions involved in social and motivational behaviors, selectively vulnerable to frontotemporal dementia and more functionally connected to the anterior hippocampus could be clearly differentiated from posterior parieto-occipital and cerebellar regions involved in spatial cognition, selectively vulnerable to Alzheimers disease, and more functionally connected to the posterior hippocampus. These findings place the human hippocampus at the interface of two major brain systems defined by a single distinct molecular gradient. (148/150)