PT  - JOURNAL ARTICLE
AU  - Ana C. Vicente
AU  - Francisca H. Guedes-da-Silva
AU  - Carlos H. Dumard
AU  - Vivian N. S. Ferreira
AU  - Igor P. S. da Costa
AU  - Ruana A. Machado
AU  - Fernanda G. Q. Barros-Aragão
AU  - Rômulo L. S. Neris
AU  - Júlio S. Dos-Santos
AU  - Iranaia Assunção-Miranda
AU  - Claudia P. Figueiredo
AU  - André A. Dias
AU  - Andre M. O. Gomes
AU  - Herbert L. de Matos Guedes
AU  - Andrea C. Oliveira
AU  - Jerson L. Silva
TI  - Yellow Fever Vaccine Protects Resistant and Susceptible Mice Against Zika Virus Infection
AID  - 10.1101/587444
DP  - 2019 Jan 01
TA  - bioRxiv
PG  - 587444
4099  - http://biorxiv.org/content/early/2019/03/25/587444.short
4100  - http://biorxiv.org/content/early/2019/03/25/587444.full
AB  - Zika virus (ZIKV) emerged as an important infectious disease agent in Brazil in 2016. Infection usually leads to mild symptoms but severe congenital neurological disorders and Guillain-Barré syndrome have been reported following ZIKV exposure. The development of an effective vaccine against Zika virus is a public health priority, encouraging the preclinical and clinical studies of different vaccine strategies. Here, we describe the protective effect of an already licensed attenuated yellow fever vaccine (17DD) on type-I interferon receptor knockout mice (A129) and immunocompetent (BALB/c) mice infected with ZIKV. Yellow fever virus vaccination results in robust protection against ZIKV, with decreased mortality in the A129 mice, a reduction in the cerebral viral load in all mice, and weight loss prevention in the BALB/c mice. Despite the limitation of yellow fever (17DD) vaccine to elicit antibody production and neutralizing activity against ZIKV, we found that YF immunization prevented the development of neurological impairment induced by intracerebral virus inoculation in adult. Although we used two vaccine doses in our protocol, a single dose was protective, reducing the cerebral viral load. Different Zika virus vaccine models have been tested; however, our work shows that an efficient and certified vaccine, available for use for several decades, effectively protects mice against Zika virus infection. These findings open the possibility for using an available and inexpensive vaccine to a large-scale immunization in the event of a Zika virus outbreak.