@article {Guo121384, author = {Mengbiao Guo and Jing Yang and Yu lung Lau and Wanling Yang}, title = {RETA: An R package for whole exome and targeted region sequencing data analysis}, elocation-id = {121384}, year = {2017}, doi = {10.1101/121384}, publisher = {Cold Spring Harbor Laboratory}, abstract = {Whole exome and targeted sequencing have been playing a major role in diagnoses of Mendelian diseases, but analysis of these data involves using many complicated tools and comprehensive understanding of the analysis results is difficult.Here, we report RETA, an R package to provide a one-stop analysis of these data and a comprehensive, interactive and easy-to-understand report with many advanced visualization features. It facilitates clinicians and scientists alike to better analyze and interpret this type of sequencing data for disease diagnoses.Availability and implementation https://github.com/reta-s/reta/releasesContact yangwl{at}hku.hk}, URL = {https://www.biorxiv.org/content/early/2017/03/28/121384}, eprint = {https://www.biorxiv.org/content/early/2017/03/28/121384.full.pdf}, journal = {bioRxiv} }