@article {Hwang096438, author = {Sungmin Hwang and Su-Chan Park and Joachim Krug}, title = {Genotypic complexity of Fisher{\textquoteright}s geometric model}, elocation-id = {096438}, year = {2017}, doi = {10.1101/096438}, publisher = {Cold Spring Harbor Laboratory}, abstract = {Fisher{\textquoteright}s geometric model was originally introduced to argue that complex adaptations must occur in small steps because of pleiotropic constraints. When supplemented with the assumption of additivity of mutational effects on phenotypic traits, it provides a simple mechanism for the emergence of genotypic epistasis from the nonlinear mapping of phenotypes to fitness. Of particular interest is the occurrence of reciprocal sign epistasis, which is a necessary condition for multipeaked genotypic fitness landscapes. Here we compute the probability that a pair of randomly chosen mutations interacts sign-epistatically, which is found to decrease with increasing phenotypic dimension n, and varies non-monotonically with the distance from the phenotypic optimum. We then derive expressions for the mean number of fitness maxima in genotypic landscapes composed of all combinations of L random mutations. This number increases exponentially with L, and the corresponding growth rate is used as a measure of the complexity of the landscape. The dependence of the complexity on the model parameters is found to be surprisingly rich, and three distinct phases characterized by different landscape structures are identified. Our analysis shows that the phenotypic dimension, which is often referred to as phenotypic complexity, does not generally correlate with the complexity of fitness landscapes and that even organisms with a single phenotypic trait can have complex landscapes. Our results further inform the interpretation of experiments where the parameters of Fisher{\textquoteright}s model have been inferred from data, and help to elucidate which features of empirical fitness landscapes can be described by this model.}, URL = {https://www.biorxiv.org/content/early/2017/03/28/096438}, eprint = {https://www.biorxiv.org/content/early/2017/03/28/096438.full.pdf}, journal = {bioRxiv} }