RT Journal Article
SR Electronic
T1 Understanding neural circuit development through theory and models
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 121574
DO 10.1101/121574
A1 Leonidas M. A. Richter
A1 Julijana Gjorgjieva
YR 2017
UL http://biorxiv.org/content/early/2017/03/29/121574.abstract
AB How are neural circuits organized and tuned to achieve stable function and produce robust behavior? The organization process begins early in development and involves a diversity of mechanisms unique to this period. We summarize recent progress in theoretical neuroscience that has substantially contributed to our understanding of development at the single neuron, synaptic and network level. We go beyond classical models of topographic map formation, and focus on the generation of complex spatiotemporal activity patterns, their role in refinements of particular circuit features, and the emergence of functional computations. Aided by the development of novel quantitative methods for data analysis, theoretical and computational models have enabled us to test the adequacy of specific assumptions, explain experimental data and propose testable hypotheses. With the accumulation of larger data sets, theory and models will likely play an even more important role in understanding the development of neural circuits.