RT Journal Article
SR Electronic
T1 Single-Cell Statistical Thermodynamics in Early Embryo Development
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 123554
DO 10.1101/123554
A1 Alessandro Giuliani
A1 Masa Tsuchiya
A1 Kenichi Yoshikawa
YR 2017
UL http://biorxiv.org/content/early/2017/04/03/123554.abstract
AB A statistical thermodynamics approach to biological regulation provides a phenomenological description of the dynamics of genome expression in terms of autonomous self-organization with a critical transition (Self-Organized Criticality). In early mouse embryo development, the dynamical change in the self-organization of overall expression determines how and when reprogramming of the genome-expression state occurs. Reprogramming occurs via a transition state (climbing over an epigenetic landscape), where the critical-regulation pattern of the zygote state disappears. A critical transition is well captured in terms of the bimodality of expression ensembles, which reflects distinct thermodynamic states (critical states). These critical states exhibit a genome avalanche pattern: competition between order (scaling) and disorder (divergence) around a critical point. The genome avalanche in mouse embryo development, which is committed to erase a previous ordered state, reveals that the direction of early embryo single-cell development traverses the same steps as in differentiation, but in the opposite order.