RT Journal Article
SR Electronic
T1 A note on dynamical compensation and its relation to parameter identifiability
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 123489
DO 10.1101/123489
A1 Omer Karin
A1 Uri Alon
A1 Eduardo Sontag
YR 2017
UL http://biorxiv.org/content/early/2017/04/03/123489.abstract
AB We recently identified a motif for dynamical compensation (DC) – a property where a system maintains the dynamics and steady-state of a regulated variable robust in the face of fluctuations in key parameters. Such parameters are therefore unidentifiable from measurements of the regulated variable at steady-state. On the other hand, since the models showing dynamical compensation are typically non-redundant, their parameters are identifiable from experimental data. We clarify this apparent discrepancy by requiring that the parameters of DC circuits be identifiable both away from steady-state and when measuring other system variables. We use this observation to provide a definition for DC in terms of parameter identifiability and discuss its relevance for the examples provided in Karin et al.