RT Journal Article SR Electronic T1 Gene-level quantitative trait mapping in an expanded C. elegans multiparent experimental evolution panel JF bioRxiv FD Cold Spring Harbor Laboratory SP 589432 DO 10.1101/589432 A1 Luke M. Noble A1 Matthew V. Rockman A1 Henrique Teotónio YR 2019 UL http://biorxiv.org/content/early/2019/03/26/589432.abstract AB The Caenorhabditis elegans multiparental experimental evolution (CeMEE) panel is a collection of genome-sequenced, cryopreserved recombinant inbred lines useful for mapping the genetic basis and evolution of quantitative traits. We have expanded the resource with new lines and new populations, and here report updated additive and epistatic mapping simulations and the genetic and haplotypic composition of CeMEE version 2. Additive QTL explaining 3% of trait variance are detected with >80% power, and the median detection interval is around the length of a single gene on the highly recombinant chromosome arms. Although CeMEE populations are derived from a long-term evolution experiment, genetic structure is dominated by variation present in the ancestral population and is not obviously associated with phenotypic differentiation. C. elegans provides exceptional experimental advantages for the study of phenotypic evolution.