RT Journal Article SR Electronic T1 Comparative genomic evidence for self-domestication in Homo sapiens JF bioRxiv FD Cold Spring Harbor Laboratory SP 125799 DO 10.1101/125799 A1 Constantina Theofanopoulou A1 Simone Gastaldon A1 Thomas O’Rourke A1 Bridget D. Samuels A1 Angela Messner A1 Pedro Tiago Martins A1 Francesco Delogu A1 Saleh Alamri A1 Boeckx Cedric YR 2017 UL http://biorxiv.org/content/early/2017/04/08/125799.abstract AB This study identifies and analyzes statistically significant overlaps between selective sweep screens in anatomically modern humans and several domesticated species. The results obtained suggest that (paleo-)genomic data can be exploited to complement the fossil record and support the idea of self-domestication in Homo sapiens, a process that likely intensified as our species populated its niche. Our analysis lends support to attempts to capture the “domestication syndrome” in terms of alterations to certain signaling pathways and cell lineages, such as the neural crest.