PT  - JOURNAL ARTICLE
AU  - Ana M. C. Faria
AU  - Bernardo S. Reis
AU  - Daniel Mucida
TI  - Tissue adaptation: implications for gut immunity and tolerance
AID  - 10.1101/125641
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 125641
4099  - http://biorxiv.org/content/early/2017/04/08/125641.short
4100  - http://biorxiv.org/content/early/2017/04/08/125641.full
AB  - Tissue adaptation is an intrinsic component of immune cell development, influencing both resistance to pathogens and tolerance. Chronically stimulated surfaces of the body, in particular the gut mucosa, are the major sites where immune cells traffic and reside. Their adaptation to these environments requires constant discrimination between natural stimulation coming from harmless microbiota and food, and pathogens that need to be cleared. This review will focus on the adaptation of lymphocytes to the gut mucosa, a highly specialized environment that can help us understand the plasticity of leukocytes arriving at various tissue sites and how tissue-related factors operate to shape immune cell fate and function.