RT Journal Article
SR Electronic
T1 Localized and global representation of prior value, sensory evidence, and choice in male mouse cerebral cortex
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2023.06.06.543645
DO 10.1101/2023.06.06.543645
A1 Ishizu, Kotaro
A1 Nishimoto, Shosuke
A1 Ueoka, Yutaro
A1 Funamizu, Akihiro
YR 2024
UL http://biorxiv.org/content/early/2024/04/01/2023.06.06.543645.abstract
AB Adaptive behavior requires integrating prior knowledge of action outcomes and sensory evidence for making decisions while maintaining prior knowledge for future actions. As outcome- and sensory-based decisions are often tested separately, it is unclear how these processes are integrated in the brain. In a tone frequency discrimination task with two sound durations and asymmetric reward blocks, we found that neurons in the medial prefrontal cortex of male mice represented the additive combination of prior reward expectations and choices. The sensory inputs and choices were selectively decoded from the auditory cortex irrespective of reward priors and the secondary motor cortex, respectively, suggesting localized computations of task variables are required within single trials. In contrast, all the recorded regions represented prior values that needed to be maintained across trials. We propose localized and global computations of task variables in different time scales in the cerebral cortex.Competing Interest StatementThe authors have declared no competing interest.