TY - JOUR T1 - Surgically disconnected temporal pole exhibits resting functional connectivity with remote brain regions JF - bioRxiv DO - 10.1101/127571 SP - 127571 AU - David E. Warren AU - Matthew J. Sutterer AU - Joel Bruss AU - Taylor J. Abel AU - Andrew Jones AU - Hiroto Kawasaki AU - Michelle Voss AU - Martin Cassell AU - Matthew A. Howard AU - Daniel Tranel Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/04/15/127571.abstract N2 - Functional connectivity, as measured by resting-state fMRI, has proven a powerful method for studying brain systems in the context of behavior, development, and disease states. However, the relationship of functional connectivity to structural connectivity remains unclear. If functional connectivity relies on structural connectivity, then anatomical isolation of a brain region should eliminate functional connectivity with other brain regions. We tested this by measuring functional connectivity of the surgically disconnected temporal pole in resection patients (N=5; mean age 37; 2F, 3M). Functional connectivity was evaluated based on coactivation of whole-brain fMRI data with the average low-frequency BOLD signal from disconnected tissue in each patient. In sharp contrast to our prediction, we observed significant functional connectivity between the disconnected temporal pole and remote brain regions in each disconnection case. These findings raise important questions about the neural bases of functional connectivity measures derived from the fMRI BOLD signal. ER -