RT Journal Article
SR Electronic
T1 Clinical, imaging genetics and deformation based morphometry study of longitudinal changes after surgery for intractable aggressive behaviour
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 548826
DO 10.1101/548826
A1 Gouveia, Flavia V.
A1 Germann, Jürgen
A1 de Morais, Rosa M. C. B.
A1 Fonoff, Erich T.
A1 Hamani, Clement
A1 Alho, Eduardo Joaquim
A1 Brentani, Helena
A1 Martins, Ana Paula
A1 Devenyi, Gabriel
A1 Patel, Raihaan
A1 Steele, Christopher J.
A1 Gramer, Robert
A1 Chakravarty, M. Mallar
A1 Martinez, Raquel C. R.
YR 2019
UL http://biorxiv.org/content/early/2019/03/27/548826.abstract
AB Intractable aggressive behaviour is a devastating behavioural disorder that reach 30% of psychiatric aggressive patients. Neuromodulatory surgeries may be treatment alternatives to reduce suffering. We investigated the outcomes of bilateral amygdala radiofrequency ablation in four patients with intractable aggressive behaviour (life-threatening-self-injury and social aggression) by studying whole brain magnetic resonance imaging and clinical data. Post-surgery assessments revealed decreases in aggression and agitation and improvements in quality of life. Aggressive behaviour was positively correlated with serum testosterone levels and the testosterone/cortisol ratio in males. No clinically significant side effects were observed. Imaging analyses revealed preoperative amygdala volumes within normal range and confirmed appropriate lesion locations. Reduction in aggressiveness were accompanied by volumetric reduction in brain areas associated with aggressive behaviour (express genes related to aggressive behaviour), and increases in regions related to somatosensation. These findings further elucidates the neurocircuitry of aggression and suggests novel neuromodulation targets.