PT  - JOURNAL ARTICLE
AU  - Chaudhari, Rahul
AU  - Sharma, Shobhona
AU  - Patankar, Swati
TI  - Glutathione and thioredoxin systems of the malaria parasite <em>Plasmodium falciparum</em>: partners in crime?
AID  - 10.1101/128264
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 128264
4099  - http://biorxiv.org/content/early/2017/04/18/128264.short
4100  - http://biorxiv.org/content/early/2017/04/18/128264.full
AB  - In P. falciparum, antioxidant proteins of the glutathione and thioredoxin systems are compartmentalized. Some subcellular compartments have only a partial complement of these proteins. This lack of key anti-oxidant proteins in certain sub-cellular compartments might be compensated by functional complementation between these systems. By assessing the cross-talk between these systems, we show for the first time, that the glutathione system can reduce thioredoxins that are poor substrates for thioredoxin reductase (Thioredoxin-like protein 1 and Thioredoxin 2) and thioredoxins that lack access to thioredoxin reductase (Thioredoxin 2). Our data suggests that crosstalk between the glutathione and thioredoxin systems does exist; this could compensate for the absence of certain antioxidant proteins from key subcellular compartments.