TY - JOUR T1 - Tissue-specific downregulation of <em>EDTP</em> removes polyglutamine protein aggregates and extends lifespan in <em>Drosophila</em> JF - bioRxiv DO - 10.1101/130559 SP - 130559 AU - Chengfeng Xiao AU - Shuang Qiu AU - R Meldrum Robertson AU - Laurent Seroude Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/04/26/130559.abstract N2 - Drosophila egg-derived tyrosine phosphatase (EDTP, also called JUMPY) is a lipid phosphatase essential in the oogenesis and muscle function in the adult stage. Although mammalian JUMPY negatively regulates autophagy, loss-of-JUMPY causes muscle dysfunction and is associated with a rare genetic disorder centronuclear myopathy. Here we show that tissue-specific downregulation of EDTP in Drosophila non-muscle tissues, particularly glial cells, completely removes polyglutamine (polyQ) protein aggregates and improves survivor. Additionally, tissue-specific downregulation of EDTP in glial cells or motoneurons extends lifespan. We demonstrate an approach to fine-tune the expression of a disease-associated gene EDTP for the removal of polyQ protein aggregate and lifespan extension in Drosophila. ER -