TY - JOUR T1 - White Matter Extension of the Melbourne Children’s Regional Infant Brain Atlas: M-CRIB-WM JF - bioRxiv DO - 10.1101/590596 SP - 590596 AU - Sarah Hui Wen Yao AU - Joseph Yuan-Mou Yang AU - Bonnie Alexander AU - Michelle Hao Wu AU - Claire E. Kelly AU - Gareth Ball AU - Marc L. Seal AU - Peter J. Anderson AU - Lex W. Doyle AU - Jeanie L.Y. Cheong AU - Alicia J. Spittle AU - Deanne K. Thompson Y1 - 2019/01/01 UR - http://biorxiv.org/content/early/2019/03/28/590596.abstract N2 - Background Understanding typically developing infant brain structure is crucial in investigating neurological disorders of early childhood. Brain atlases providing standardised identification of neonatal brain regions are key in such investigations. Our previously developed Melbourne Children’s Regional Infant Brain (M-CRIB) and M-CRIB 2.0 neonatal brain atlases provide standardised parcellation of 100 and 94 brain regions respectively, including cortical, subcortical, and cerebellar regions. The aim of this study was to extend the M-CRIB atlas coverage to include 54 white matter regions.Methods Participants were ten healthy term-born neonates who comprised the sample for the M-CRIB and M-CRIB 2.0 atlases. WM regions were manually segmented on T2 images and co-registered diffusion tensor imaging-based, direction-encoded colour maps. Our labelled regions are based on those in the JHU-neonate-SS atlas, but differ in the following ways: 1) we included five corpus callosum subdivisions instead of a left / right division; 2) we included a left / right division for the middle cerebellar peduncle; and 3) we excluded the three brainstem divisions. All segmentations were reviewed and approved by a paediatric radiologist and a neurosurgery research fellow for anatomical accuracy.Results The resulting neonatal WM atlas comprises 54 WM regions: 24 paired regions, and six unpaired regions comprising five corpus callosum subdivisions and one pontine crossing tract. Detailed protocols for manual WM parcellations are provided, and the M-CRIB-WM atlas is presented together with the existing M-CRIB and M-CRIB 2.0 cortical, subcortical and cerebellar parcellations in ten individual neonatal MRI datasets.Conclusion The updated M-CRIB atlas including the WM parcellations will be made publicly available. The atlas will be a valuable tool that will help facilitate neuroimaging research into neonatal WM development in both healthy and diseased states.AALAutomated Anatomical LabellingACRAnterior Corona RadiataALICAnterior Limb of Internal CapsuleANTsAdvanced Normalization ToolsAPAnterior-PosteriorBETBrain Extraction ToolCCCorpus CallosumCGCCingulum Cingular PartCGHCingulum Hippocampal PartCPCerebellar PeduncleCRCorona RadiataCSTCorticospinal TractsDECDirection-Encoded ColourDTIDiffusion Tensor ImagingDWIDiffusion Weighted ImagesECExternal CapsuleEPIEcho Planar ImagingFLIRTFunctional Magnetic Resonance Imaging of the Brain’s Linear Image Registration ToolFMRIFunctional Magnetic Resonance ImagingFOVField of ViewFSLFunctional Magnetic Resonance Imaging Software LibraryFUGUEFMRIB’s Utility for Geometrically Unwarping Echo planar imagesFxFornixGMGrey MatterICInternal CapsuleICPInferior Cerebellar PeduncleIFOInferior Fronto-Occipital FasciculusITKInsight ToolkitJHUJohns Hopkins UniversityLRLeft-RightMCPMiddle Cerebellar PeduncleM-CRIBMelbourne Children’s Regional Infant BrainM-CRIB-WMMelbourne Children’s Regional Infant Brain-White MatterMLMedial LemniscusMRIMagnetic Resonance ImagingPCRPosterior Corona RadiataPCTPontine Crossing TractPLICPosterior Limb of Internal CapsulePTRPosterior Thalamic RadiationRLICRetrolenticular Part of Internal CapsuleSCPSuperior Cerebellar PeduncleSCRSuperior Corona RadiataSFOSuperior Fronto-Occipital FasciculusSISuperior-InferiorSLFSuperior Longitudinal FasciculusSSSagittal StratumSTStria TerminalisTAPTapetumTEEcho TimeTRRepetition TimeUFCUncinate FasciculusWMWhite Matter ER -