PT  - JOURNAL ARTICLE
AU  - Louise P. Kirsch
AU  - Sahba Besharati
AU  - Christina Papadaki
AU  - Laura Crucianelli
AU  - Sara Bertagnoli
AU  - Nick Ward
AU  - Valentina Moro
AU  - Paul M. Jenkinson
AU  - Aikaterini Fotopoulou
TI  - Damage to the Right Insula Disrupts the Perception of Affective Touch
AID  - 10.1101/592014
DP  - 2019 Jan 01
TA  - bioRxiv
PG  - 592014
4099  - http://biorxiv.org/content/early/2019/03/28/592014.short
4100  - http://biorxiv.org/content/early/2019/03/28/592014.full
AB  - Specific, peripheral C-tactile afferents contribute to the perception of tactile pleasure, but the brain areas involved in their processing remain debated. We report the first human lesion study on the perception of C-tactile touch (N = 59), revealing that posterior and anterior right insula lesions reduce tactile, contralateral and ipsilateral pleasantness sensitivity, respectively. These findings are consistent with a posterior-to-anterior pattern of integration of interoceptive information in the frontoinsular junction.