RT Journal Article SR Electronic T1 Damage to the Right Insula Disrupts the Perception of Affective Touch JF bioRxiv FD Cold Spring Harbor Laboratory SP 592014 DO 10.1101/592014 A1 Louise P. Kirsch A1 Sahba Besharati A1 Christina Papadaki A1 Laura Crucianelli A1 Sara Bertagnoli A1 Nick Ward A1 Valentina Moro A1 Paul M. Jenkinson A1 Aikaterini Fotopoulou YR 2019 UL http://biorxiv.org/content/early/2019/03/28/592014.abstract AB Specific, peripheral C-tactile afferents contribute to the perception of tactile pleasure, but the brain areas involved in their processing remain debated. We report the first human lesion study on the perception of C-tactile touch (N = 59), revealing that posterior and anterior right insula lesions reduce tactile, contralateral and ipsilateral pleasantness sensitivity, respectively. These findings are consistent with a posterior-to-anterior pattern of integration of interoceptive information in the frontoinsular junction.