RT Journal Article
SR Electronic
T1 Maternal Immunoglobulin A regulates the development of the neonatal microbiota and intestinal microbiota-specific CD4+ T cell responses
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2024.06.10.598156
DO 10.1101/2024.06.10.598156
A1 Abbott, Darryl A.
A1 Rai, Ali T.
A1 Yang, Aaron
A1 Cai, Yixuan
A1 Fabre, Shelcie
A1 Frazer, Austin J.
A1 Deschepper, Jacob D.
A1 Poholek, Amanda C.
A1 Hand, Timothy W.
YR 2024
UL http://biorxiv.org/content/early/2024/06/11/2024.06.10.598156.abstract
AB Breast milk is a complex mixture of nutrients and bioactives that promote infant development and decrease the incidence of chronic inflammatory disease. We investigated the role of one milk-derived bioactive, Immunoglobulin A (IgA) on the developing small intestinal microbiota and immune system. We demonstrate that early in life, milk-derived IgA suppressed colonization of the small intestine by Enterobacteriaceae and regulated the maturation of the small intestinal epithelium and the development of intestinal IL-17-producing CD4+ T cells. Enterobacteriaceae- specific CD4+ T cells, induced in the first weeks of life in the absence of milk-derived IgA, persisted in the intestine as memory T cells that can contribute to inflammatory disease later in life. Our study suggests that milk-derived IgA shapes mucosal immunity by regulating the neonatal microbiota thus preventing the development of long-lived intestinal microbiota-specific T cells.Competing Interest StatementThe authors have declared no competing interest.