TY - JOUR T1 - Negative correlation between the expression of <em>tlr4</em> and <em>grp78</em> is characteristic of sepsis onset and progression JF - bioRxiv DO - 10.1101/133264 SP - 133264 AU - Razvan C. Stan AU - Camila P. Bonin AU - Rose Porto AU - Francisco G. Soriano AU - Maristela M. de Camargo Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/05/02/133264.abstract N2 - In sepsis caused by Gram-negative bacteria, modulation of Toll-like receptor 4 (TLR4) activity by modulators such as glucose-regulated protein 78 kDa (GRP78), is believed to shift the equilibrium between pro- and anti-inflammatory downstream signaling cascade. We measured daily mRNA tlr4 and grp78 expression levels in peripheral blood of a cohort of septic patients, upon intensive care admission, and modeled these mRNA values based on a sine damping function. We obtained negative correlations between tlr4 and grp78 mRNA in the survivor group. In contrast, such relation is lost in the deceased patients. Effect sizes were 2.035 (tlr4) and 2.168 (grp78). Measuring the correlation patterns of the expression of these two genes may serve as a robust means to gauge sepsis progression, requiring three points of measurement on the first day of hospitalization. Higher levels of grp78 and lower levels of tlr4 anticipated a positive evolution of sepsis, resulting in patient survival. ER -