RT Journal Article
SR Electronic
T1 Ultrafast and accurate sequence alignment and clustering of viral genomes
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2024.06.27.601020
DO 10.1101/2024.06.27.601020
A1 Zielezinski, Andrzej
A1 Gudyś, Adam
A1 Barylski, Jakub
A1 Siminski, Krzysztof
A1 Rozwalak, Piotr
A1 Dutilh, Bas E.
A1 Deorowicz, Sebastian
YR 2024
UL http://biorxiv.org/content/early/2024/07/02/2024.06.27.601020.abstract
AB Viromics produces millions of viral genomes and fragments annually, overwhelming traditional sequence comparison methods. We introduce Vclust, a novel approach that determines average nucleotide identity by Lempel-Ziv parsing and clusters viral genomes with thresholds endorsed by authoritative viral genomics and taxonomy consortia. Vclust demonstrates superior accuracy and efficiency compared to existing tools, clustering millions of virus genomes in a few hours on a mid-range workstation.Competing Interest StatementThe authors have declared no competing interest.