PT  - JOURNAL ARTICLE
AU  - Tagui, Yurika
AU  - Takeda, Shingo
AU  - Waida, Hiroyo
AU  - Kitahara, Shoichi
AU  - Kimura, Tomoki
AU  - Kanda, Shinji
AU  - Oka, Yoshitaka
AU  - Hayashi, Yu
AU  - Umatani, Chie
TI  - AgRP1 modulates breeding season-dependent feeding behavior in female medaka
AID  - 10.1101/2024.07.10.602830
DP  - 2024 Jan 01
TA  - bioRxiv
PG  - 2024.07.10.602830
4099  - http://biorxiv.org/content/early/2024/07/29/2024.07.10.602830.short
4100  - http://biorxiv.org/content/early/2024/07/29/2024.07.10.602830.full
AB  - Feeding and reproduction are known to be closely correlated with each other, and the seasonal breeders show breeding season-dependent feeding behavior. However, most model animals do not have definite breeding seasonality, and the mechanisms for such feeding behavior remain unclear. Here, we focused on female medaka (Oryzias latipes); they show breeding season-dependent feeding behavior, and their condition of breeding season can be experimentally controlled by day-length. We first demonstrated that, among previously reported feeding-related peptides (neuropeptides involved in feeding), agouti-related peptide 1 (agrp1) and neuropeptide y b (npyb) show higher brain expression under the breeding condition than under the non-breeding one. Combined with analysis of agrp1 knockout medaka, we obtained results to suggest that long day-induced sexually mature condition, especially ovarian estrogenic signals, increase the expressions of agrp1 in the brain, which results in increased food intake to promote reproduction. Our findings advance the understanding of neural mechanisms of feeding behavior for reproductive success.Competing Interest StatementThe authors have declared no competing interest.