RT Journal Article
SR Electronic
T1 AgRP1 modulates breeding season-dependent feeding behavior in female medaka
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2024.07.10.602830
DO 10.1101/2024.07.10.602830
A1 Tagui, Yurika
A1 Takeda, Shingo
A1 Waida, Hiroyo
A1 Kitahara, Shoichi
A1 Kimura, Tomoki
A1 Kanda, Shinji
A1 Oka, Yoshitaka
A1 Hayashi, Yu
A1 Umatani, Chie
YR 2024
UL http://biorxiv.org/content/early/2024/07/29/2024.07.10.602830.abstract
AB Feeding and reproduction are known to be closely correlated with each other, and the seasonal breeders show breeding season-dependent feeding behavior. However, most model animals do not have definite breeding seasonality, and the mechanisms for such feeding behavior remain unclear. Here, we focused on female medaka (Oryzias latipes); they show breeding season-dependent feeding behavior, and their condition of breeding season can be experimentally controlled by day-length. We first demonstrated that, among previously reported feeding-related peptides (neuropeptides involved in feeding), agouti-related peptide 1 (agrp1) and neuropeptide y b (npyb) show higher brain expression under the breeding condition than under the non-breeding one. Combined with analysis of agrp1 knockout medaka, we obtained results to suggest that long day-induced sexually mature condition, especially ovarian estrogenic signals, increase the expressions of agrp1 in the brain, which results in increased food intake to promote reproduction. Our findings advance the understanding of neural mechanisms of feeding behavior for reproductive success.Competing Interest StatementThe authors have declared no competing interest.